Plabst et al., "Maternal vitamin D intake during pregnancy increases gene expression of ILT3
and ILT4 in cord blood," Clinical and Experimental Allergy, vol.
ILT3 e ILT4 juegan un papel importante en la maduracion de celulas T CD4+ virgenes hacia Treg.
Central role of ILT3 in the T suppressor cell cascade.
These so-called DC-10 are tolerogenic DCs and characterized by the high expression intensities of HLA-G1, ILT2, ILT4, and ILT3 and their production of high IL-10 levels.
Krishnan, "Rapamycin downregulates the inhibitory receptors ILT2, ILT3, ILT4 on human dendritic cells and yet induces T cell hyporesponsiveness independent of FoxP3 induction," Immunology Letters, vol.
To date, we have observed one coding-change polymorphism in the ILT3 receptor which is associated with TNF-[alpha] levels in SLE patients .
Niewold, "Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients," Annals of the Rheumatic Diseases, vol.
Amuchastegui et al., "Expression of the inhibitory receptor ILT3
on dendritic cells is dispensable for induction of [CD4.sup.+][Foxp3.sup.+] regulatory T cells by 1,25-dihydroxyvitamin D3," Blood, vol.
The following combination of antibodies wasusedtocharacterizethe phenotypeofMDDCs: (a) MHCIIFITC (mouse IgG2a k), SLAMF1 PE (mouse IgG1 k), CD11c PerCP-eFluor 710 (mouse IgG1 k), and B7/H1 APC (mouse IgG1 k); (b) CD83 FITC, CD80 PE, CD11c PerCP-eFluor 710 (mouse IgG1 k), and CD86 APC (mouse IgG1 k); (c) CD205 FITC (mouse IgG2b k), CD40 PE (mouse IgG1 k), CD11c PerCP-eFluor 710 (mouse IgG1 k), and ILT3
APC (mouse IgG1 k).