IMGUInsulin-Mediated Glucose Uptake
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The relationship between direct and surrogate estimates of IMGU varies with BMI, with the weakest correlations seen in the normal-weight group and the strongest in the obese group irrespective of the pattern of obesity (33).
However, as IMGU was still decreased in PCOS which indicate that increased IRS-2 associated PI3K activity could not completely compensate for the defect.
In contrast to in vivo studies, basal and IMGU was significantly high in the cultured myotubes from obese PCOS women (68).