tuberculosis and that contribute to the formation of the granuloma are the invariant natural killer T (
iNKT) cells.
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In HDC-deficient mice, a decrease in H4R expression on
iNKT cells is associated with lower production of IL-4 and IFN-[gamma] by those cells, which demonstrates regulation between these factors [26].
Smith, "IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th 2 cells,
iNKT and NK Cells," International Immunology, vol.
Type I NKT cells, or
iNKT cells, are characterized by the expression of a semi-invariant TCR (V[alpha]24J[alpha]18V[beta]11 in humans and V[alpha]14J[alpha]18 paired with a limited repertoire of V[beta] chains in mice) and by the recognition of the lipid antigen [alpha]-galactosylceramide ([alpha]-GalCer) [82].
Immune infiltrates in invasive cervical cancer: Immune tolerance in cervical cancer is thought to be due to various reasons: tolerogenic DCs, invariant natural killer T cells (
iNKT), [gamma][delta] cells, anergic cytotoxic T cells (CTLs), and Tregs, to name but a few.
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Lanier, "miR-150 regulates the development of NK and
iNKT cells," The Journal of Experimental Medicine, vol.
CD73 (Nt5e) PAP (Acpp) Thymus [gamma][delta] T [gamma][delta] T cells ** cells ** CD4 single positive
iNKT precursors ** Double negative thymocytes CD8 single positive, mature
iNKT *** precursors ** Lymph nodes CD4 memory CD8 naive CD8 naive CD8 memory Treg Blood endothelial cells Spleen Germinal center B CD4 naive cells Memory B cells CD4 memory [gamma][delta] T [gamma][delta] T cells ** cells ** CD4 naive CD8 naive CD4 memory CD8 memory CD8 naive CD8 memory
iNKT cells Treg
iNKT cells NK cells ** * The data has been collected from the Immunological Genome Project (http://www.immgen.org/databrowser).
Hogquist, "Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of
iNKT cells," Nature Immunology, vol.