(28) As described above, L-PGDS, brain-type Tf, and sAPP are all decreased in iNPH (Fig.
As such, protein levels decrease in iNPH, in which the brain is compressed by excess CSF.
Fifteen patients with INPH and eight reference subjects were included in the study.
As a result, the authors described ventricular reflux and transependymal migration from the lateral ventricles towards the periventricular white matter in patients with INPH as characteristic findings of NPH.
The neurologic insults that can result in PBA may include CP or iNPH. Cerebellar injury is a frequent pathological finding in CP.
X previously received a ventriculoperitoneal shunt for treating iNPH. He was not taking any medications for CP.
One-year outcome in the European multicentre study on iNPH
. Acta Neurologica Scandinavica, 726, 145-53.
In considering the possibility of iNPH, we ordered a repeat brain MRI (Figure 1).
From a clinical viewpoint, gait dysfunction is mandatory to diagnose iNPH. At least one more abnormality, namely, urinary symptoms or cognitive impairment, is required to support a probable diagnosis .
In aging societies, the incidence of age-related diseases, such as iNPH
, has been increasing and shunt interventions for iNPH
have improved patient outcomes .
No single test has sufficient sensitivity to rule out the diagnosis of INPH
(SOR: B, based on systematic review of small RCT and prospective trials).
First described by Hakim and Adams in 1965, idiopathic normal pressure hydrocephalus (INPH
) is an enlargement of cerebral ventricles (Fig 1) without evidence of chronic increased intracranial pressure (ICP).