These initial experiments demonstrate that contrast agents can be successively imaged in IPRL. The Gd-DTPA perfusion estimates the signal intensity increase associated with the extracellular volume distribution.
In these preliminary studies, we show that IPRL is an interesting model to quantify liver concentrations of imaging radiotracers and contrast agents and to assess their temperature dependence.
In the IPRL, we investigate two new parameters to assess Mrp2 transport function: the gradients between Gd-BOPTA hepatocyte and bile concentrations over the perfusion period, and a unique parameter named canalicular concentration ratio (CCR) that represents the slope of the nonlinear regression curve between hepatocyte and bile concentrations .
Our investigations clearly show that MR contrast agents can be imaged in IPRL. With our experimental protocol, the Gd-DTPA perfusion estimates the signal intensity increase associated with the extracellular volume distribution.