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Serum iPTH level was obtained 6 hours post-operatively.
Demographic information about the patients' age, gender, ESRD etiology, hospital type, duration of dialysis, HD frequency (times/week), urea reduction ratio, single pool-Kt/V (spKt/V), pre-dialysis systolic blood pressure (SBP), pre-dialysis diastolic blood pressure (DBP), serum hemoglobin, calcium, phosphorus, and iPTH levels were collected.
Two months after initiating treatment with etelcalcetide, the dose was increased to 10 mg after each hemodialysis session due to lack of control in iPTH levels and one month later treatment with Pamidronate was stopped due to the appearance of severe maintained hypocalcemia.
The median values of the laboratory test results for hemoglobin, iPTH, albumin, and phosphorus were in agreement with that recommended for this population.
The first step for evaluating the cause of hypercalcemia is the measurement of iPTH; then, the possibility of cancer should be considered in the setting of low serum iPTH concentration .
Physical examination and laboratory evaluation after the completion of the first cycle of chemotherapy revealed liver span, and the spleen decreased in size from 20 cm to 8 cm and 4 cm below left costal margin to just palpable., respectively Also, the serum calcium level had decreased to 12.1 mg/dl, the phosphate level increased to 3.4 mg/dl, and the intact parathyroid hormone (iPTH) level had increased to 7.75 (normal range 15-65) pg/ml.
In agreement, previously, it has been reported that low, rather than high, iPTH was associated with inflammation and oxidative stress, as a result of MIA syndrome .
Serum iPTH levels were higher in patients with DTC, 5 without statistical significance (p=0.10); however, in the logistic regression model, that included age, PTH, gender, serum calcium, and vitamin D, they showed a significantly association between preoperative PTH levels and the presence of DTC (p=0.03), with an estimated odds ratio of 5.16 (95% confidence interval [CI] 1.08-24.7) (Table 3).
The intact PTH (iPTH) level in the aspirated cystic fluid was measured, and the aspirated cell cluster was cytopathologically examined.
In the biochemical analyses, test results were determined as serum calcium of 16.6 mg/dL (reference range 8.5-10.1 mg/dL) and an intact parathyroid hormone level (iPTH) of 744 pg/mL (reference range 11-67 pg/mL).
Blood sample (10 ml) was drawn and the following investigations were performed: Fasting blood glucose, fasting serum insulin levels, lipid profile, intact (PTH) iPTH, vitamin D levels, serum ionic calcium, serum phosphorus, and alkaline phosphatase.
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- IPT lowdose chemotherapy
- IPTC IIM
- IPtimize Management Center