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IRF-4Interferon Regulatory Factor 4
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Another factor implicated in DC development is IRF-4. IRF-4-deficient mice lacked the majority of splenic [CD11b.sup.+] [CD4.sup.+] [CD8.sup.-] cDCs and had a slight reduction in pDCs [129, 130].
Conversely, the elevated levels of IRF-4 mRNA in [E4BP4.sup.-/-] cells indicate that E4BP4 inhibits IRF-4, directly or indirectly (Figure 1(a)).
IRF-5 competes with IRF-4 for binding to the signaling adapter MyD88 and the downstream subsequent activation of proinflammatory transcription factors [27].