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IRF3Interferon Regulatory Factor 3
IRF3IFN Regulatory Factor 3
References in periodicals archive ?
The new studies found that the HIV protein vpu specifically binds to the immune protein IRF3 and targets it for destruction, thereby, preventing IRF3 from functioning to trigger an immune response within the infected cell.
This knowledge can be used to design new HIV antiviral therapeutics that prevent vpu from interacting with IRF3 and targeting it for destruction, thus enhancing immunity.
This model of action is consistent with the ability of NS1 expression to prevent activation of transcription factors involved in the induction of IFN[alpha]/[beta] synthesis, including IRF3 (16).