References in periodicals archive ?
Smallie et al., "IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses," Nature Immunology, vol.
(2014) Transcription factor IRF5 drives P2X4R+ reactive microglia gating neuropathic pain.
Wu et al., "Genetic association study of TNFAIP3, IFIH1, IRF5 polymorphisms with polymyositis/dermatomyositis in Chinese Han population," PLoS ONE, vol.
Yin, "Relationship between polymorphism sites of IRF5, TLR-9 and SLE patients in Shandong Han population," Zhonghua Yi Xue Za Zhi, vol.
The study has suggested that blocking the production of IRF5 in macrophages may help treat autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease, lupus, and multiple sclerosis.
Several lines of evidence implicate the interferon pathway in SLE pathogenesis, and thus the report in 2005 by Sigurdsson and coworkers (32) of genetic association with the interferon regulatory factor 5 (IRF5) gene among Swedish and Finnish SLE cases and controls quickly led to attempts at replication in other populations.
These effects may be attributed to the phenotypic transformation, which is in part regulated by the suppressor of cytokine signaling (SOCS) 1/SOCS3 and interferon regulatory factor (IRF) 4/ IRF5 [6-9].
mRNA expression of TBX21 (T-helper 1 (Th1) response), GATA3 (T-helper 2 (Th2) response), RORC (T-helper 17 (Th17 response), FOXP3 (Treg marker), Interleukin 6 (IL6), IL1b, interferon-[gamma] (IFN[gamma]), CD68 (macrophage), IRF5 (M1 macrophages), and MRC1 (M2 macrophages) was analyzed using TaqMan On-Demand-Gene-Expression Assays (Thermo Fisher, USA).
Brief report: IRF5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of children with neonatal lupus.
Analysis has shown polymorphisms in the IFN regulatory factor 5 (IRF5) gene, a gene that has been associated other autoimmune diseases, with a haplotype that appears to offer a protective effect in WG.
Garnier et al., "A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5," Human Molecular Genetics, vol.
They have found a protein called IRF5 that acts as a switch, telling immune system cells, called macrophages, to promote or stop inflammation, reports the Daily Express.
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