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IRS1Diabetes Mellitus, Noninsulin-Dependent
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Real time PCR analysis showed a significant reduction in mRNA abundance for GLUT4, IRS1, ACACA and FASN in adipose tissue of male offspring of treated females compared with controls (p < 0.
Association of Gly972Arg polymorphism of IRS1 gene with type 2 diabetes mellitus in lean participants of a national health survey in Mexico: a candidate gene study.
5A), and marein rescued the increased IRS1 protein levels caused by treatment with high glucose concentrations (Fig.
In vascular smooth muscle cells (VSMC), Ang II-elicited ERK1/2 activation leads to phosphorylation of IRS1 at Ser307 and Ser616, thereby inhibiting AKT activation and ultimately suppressing the insulin-induced glucose uptake [27].
Considerando las anteriores premisas y la diversidad de la poblacion mexicana, se requiere hacer mas estudios de replica de genes asociados, como el realizado en diabeticos de las ciudades de Guerrero y Mexico en el que solo se encontro asociacion para variantes en IRS1 y TCF7L2 (39).
Effect of the Gly972Arg, SNP43 and Prol2Ala polymorphisms of the genes IRS1, CAPN10 and PPARG2 on secondary failure to sulphonylurea and metformin in patients with type 2 diabetes in Yucatan, Mexico.
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
In the present study, we aimed to test whether circulating 25(OH)D could modify associations of IRS1 variant rs2943641 with T2D and IR in Boston-based Puerto Rican adults.
In addition to the previous mechanisms, studies have shown that IRS1 and IRS2 interact with cytosolic transport proteins 14-3-3 through phosphoserine residues within the PTB domain and this binding may physically prevent the interaction with the insulin receptor (24).
IRS1, Insulin receptor substrate Plays a key role in transmitting (2) signals from the insulin & IGF-1 to intracellular pathway.
NE degrades IRS1, a key protein in the insulin signaling pathway in both liver and fat cells.
Burguete-Garcia focused on AKNA as a genetic risk factor for cervical intraepithelial neoplasia and cervical cancer, the association of Interleukin-10 gene promoter polymorphisms and gene expression in HPV cervical lesions, and the association of the Gly972Arg polymorphism of the IRS1 gene with type 2 diabetes mellitus in lean participants of a national health survey in Mexico (9-11).