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ISGF3Interferon-Stimulated Gene Factor 3
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10) This pathway involves activation of TANK-binding kinase 1 (TBK1) and I[kappa]B kinase [epsilon] (IKK[epsilon]) followed by nuclear translocation of IRF7, a transcription factor acting directly as a transcription factor for type I IFN promoter and indirectly through its induction of type I IFN and the latter's induction of ISGF3.
Type I IFNs induce formation of ISGF3 which complexes with a 48 kDa DNA binding protein and binds to ISREs.
This process promotes generation of the ISGF3 transcription factor, a complex of STAT1, STAT2, and IRF9 that accumulates in the nucleus.