ISKDCInternational Study of Kidney Disease in Children
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ISKDC (International Study of Kidney Diseases in Children) Criteria for nephrotic syndrome were eligible for inclusion:
One purpose of the ISKDC (1978, 1981) study was to further evaluate the accuracy of identifying the underlying glomerular disease based on clinical presentation to avoid the need of performing a renal biopsy prior to starting treatment.
Over the years, since the findings of the ISKDC study were published, there have been changes in the population that present with nephrotic syndrome.
The ISKDC study (1981) set dosing guidelines, and these then became the control group for randomized control studies that followed.
The question of when to perform a renal biopsy has been an ongoing discussion since the ISKDC (1978, 1981) published its recommendations.
(18.) ISKDC Primary Nephrotic syndrome in Children Kidney Int.1981, 20 765.
Two-year outcome of the ISKDC regimen and frequent-relapsing risk in children with idiopathic Nephrotic syndrome.
All children were subjected to International Study of Kidney Diseases in Children (ISKDC) classification for diagnosis of nephrotic syndrome.