ITGALIntegrin AlphaL
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Next, the protein-protein interaction (PPI) network was evaluated and top degree hub genes were listed: ubiquitin A-52 residue ribosomal protein fusion product 1 (UBA52), ribosomal protein L38 (RPL38), integrin subunit alpha L (ITGAL), intercellular adhesion molecule 1 (ICAM1), interleukin 7 receptor (IL7R), interleukin 7 (IL7), REL protooncogene, NF-KB subunit (REL) and NF-KB inhibitor alpha (NFKBIA), Vav guanine nucleotide exchange factor 1 (VAV1), and lymphocyte cytosolic protein 2 (LCP2).
(a) System Antigens CD Gene cDNA sequence HNA-1 HNA-1a CD16 FCGR3B (b) NM_000570.4 HNA-1b HNA-1c HNA-1d HNA-2 HNA-2a CD177 CD177 NM_020406.2 HNA-3 HNA-3a CTL2 (c) SLC44A2 NM_020428.3 HNA-3b HNA-4 HNA-4a CD11a ITGAM NM_001145808.1 HNA-4b HNA-5 HNA-5a CD11b ITGAL NM_001114380.1 HNA-5b (a) Veldhuisen et al.
We previously demonstrated that inhibition of DNA methylation in T cells resulted in the demethylation of regulatory sequences and increased gene expression of CD11a (ITGAL) and CD70 (TNFSF7) [2-4].