The plasma glucose and insulin levels measured periodically during IVGTT
were used to calculate AUCs as indexes of glucose intolerance and insulin secretion, respectively.
As we know, the impairment of first-phase insulin secretion is a common characteristic in IGR and T2DM; thus, we examined the effects of IVGTT
on plasma asprosin levels in the first phase and compared its secretion pattern with insulin.
Three days following IVGTT
, skeletal muscle biopsies were obtained under anesthesia and sterile conditions in all pigs.
For the IVGTT
, fasting blood glucose concentrations were determined (time interval 0) as previously described by Sinsigalli et al.
After adaptation period, Intravenous glucose tolerance test (IVGTT
) experiment was applied to make sure of the absence of diabetes.
On the last 2 days of each condition, we assessed glucose metabolism by intravenous glucose tolerance test (IVGTT
) and euglycemic-hyperinsulinemic clamp.
derece akrabalarinda otoantikorlara bakilmasi ve bunlara IVGTT
(intravenoz Glukoz Tolerans Testi) yapilarak 1.
Twelve male domestic shorthair cats were tested using an intravenous arginine test (IVAST), a meal response test (MRT) and an IV glucose response test (IVGTT
It is highly correlated with the acute insulin response (AIR) on intravenous glucose tolerance test (IVGTT
) and is considered a reasonable surrogate [5,6].
The following parameters were evaluated: homeostasis model assessment (HOMA)-IR, HOMA-[sz], modified [sz]-cell function index (MBCI), peak insulin/fasting insulin (I[sub]P/I[sub]0), AUC[sub]ins-OGTT, and AUC[sub]ins-OGTT/AUC[sub]glu-OGTTfrom the oral glucose tolerance test (OGTT) insulin release test were utilized to assess the second-phase insulin secretion, while the I[sub]P/I[sub]0, AIR[sub]0′~10′, and AUC[sub]ins-IVGTTfrom the intravenous glucose tolerance test (IVGTT
) insulin release test were used to assess the first-phase insulin secretion.
An empirical index of insulin sensitivity from short IVGTT
: validation against the minimal model and glucose clamp indices in patients with different clinical characteristics.
We therefore decided to investigate whether TNF-[alpha] would have an acute effect on BIS as well as the insulin response to an intravenous glucose tolerance test (IVGTT