There are over 200 cases reported worldwide of renal adverse events following IVIG
Treatment beyond the standard KD protocol (aspirin + IVIg
) was necessary in all but one patient.
On contrary, the side effects associated with the use of IVIG
infusion would restrict the market growth to an extent.
In the present study, our results showed that circulating Th1, Th17, and Th22 cells as well as the levels of IL-17 and IL-22 in plasma were obviously elevated in GBS at the acute phase and IVIg
treatments could downregulate these cells and their cytokines at the plateau phase of GBS.
They were treated by IVIG
for more than 3 months at the beginning of observation (range 3-58 months).
Patients with KD who were admitted to Chang Gung Children's Hospital (Kaohsiung, Taiwan) from February 2008 to March 2011 and treated with IVIG
(2g/kg), followed by low-dose aspirin (3-5 mg/kg/day as a single daily dose) until all signs of inflammation had resolved, were enrolled in the study.
Intravenous Immunoglobulin (IVIg
), a compound comprising of immune proteins (globulins) is administered into the bloodstream to treat patients with inefficient or damaged immune systems.
Therefore, corticosteroid and IVIg
treatment is applied to prevent the autoantibody development during the treatment (2).
All of the patients were treated with an initial IVIg
dose of 0.4 gr/kg/day for 5 consecutive days, and then 0.4 gr/kg for each month.
Rooney said he calculated the potential award for the child after seeing how she proceeded with school and in her social life while needing the IVIG
on a regular basis.
While conventional vasodilator strategies appeared to be of limited benefit, the combination of immunosuppression and IVIG
was associated with improvement and eventual recovery.
However, current practice at Children's Hospital of Philadelphia is to initiate IVIG
therapy at AFM diagnosis in hopes of boosting humoral immunity.