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ICSBPInterferon Consensus Sequence Binding Protein
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References in periodicals archive ?
Sestili et al., "ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of [CD8.[alpha].sup.+] dendritic cells," Journal of Experimental Medicine, vol.196, no.11, pp.1415-1425, 2002.
Reduced expression of TNF[alpha] receptors appears to be associated with the G allele that encodes for the binding site of the interferon consensus sequence-binding protein (ICSBP, also known as IRF8 or interferon regulatory factor 8), a transcription factor that is involved in TNFRI-mediated activation of NF-[kappa]B signaling pathway 43].
IRF-8, also known as interferon consensus sequence-binding protein (ICSBP), is a 393-amino acid-long "hematopoietic" IRF [22].