IGFBPInsulin-Like Growth Factor Binding Protein
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The IGF family consists of two IGF ligands (IGF-1 and IGF-2), three cell surface receptors (IGF-1 and IGF-2 receptors and the insulin receptor), and six IGF binding proteins (IGFBPs) [1].
Structure and characterization of the human insulin-like growth factor binding protein (Igfbp)-6 promoter: identification of a functional retinoid response element.
In mammals, six well characterized IGFBPs have been observed.
Localization of insulin-like growth factor (IGFBP)-3 in cultured porcine embryonic myogenic cells before and after TGF-beta1 treatment.
[6] Nonstandard abbreviations: IGF, insulin-like growth factor; IGFBP, IGF binding protein; GH, growth hormone; IUGR, intrauterine growth restriction; BW, birth weight; GA, gestational age; AGA, appropriate for gestational age; LGA, large for gestational age; SGA, small for gestational age; PI, ponderal index; IFD, intrapartum fetal distress.
The cysteine-rich IGFBP-7 protein family, which is structurally similar to the IGFBP superfamily (Hwa et al., 1999), mediates various biological functions.
[3] Nonstandard abbreviations: PAPP-A, pregnancy-associated plasma protein-A; IGFBP, insulin-like growth factor binding protein; IGF, insulin-like growth factor; proMBP, proform of eosinophil major basic protein; PBS-T, PBS containing 0.05% w/v Tween-20; and Lys(Abz), o-aminobenzoic acid-modified lysine
The authoradiographic intensity of the IGFBP band in WLB was analyzed by the General Linear Model procedure of SAS (SAS Inst., Cary, NC, USA).
The present study was designed to determine 1) the effects of the BOEC co-culture system on in vitro development rate of bovine IVM/IVF embryos, 2) the effect of status of BOEC on in vitro development of bovine embryos, and 3) detection of the temporal patterns of expression of growth factor genes (TGF, EGF and IGFBP), antioxidant genes (Cu/Zn-SOD, Mn-SOD, Catalase and GPx) and apoptosis genes (Bax, p53 and Caspase-3) in different types of BOEC co-cultured with or without bovine IVM/IVF embryos.
To improve the accuracy of the IGF-I assays, high-affinity antibodies should be used wherever possible because IGFBPs have similar affinities and compete with conventional antibodies.
Serum concentration of IGF-I, estradiol-17[beta], testosterone, and relative amounts of IGF-binding proteins (IGFBP) in growing boars, barrows, and gilts.