Three different forms of renal irAE have been described so far: acute interstitial nephritis, minimal change disease, and immune complex glomerulonephritis
Levamisole/cocaine induced systemic vasculitis and immune complex glomerulonephritis
. Case Rep Nephrol 2015; 2015:372413, doi: 10.1155/2015/372413.
Kidney biopsy did not demonstrate evidence of a proliferative glomerulonephritis, viral immune defects in glomerular cells, or an immune complex glomerulonephritis
with IgG, IgA, C3 or CMV antigens within glomeruli.
The adverse effects include proteinuria, glomerulitis with haematuria, Membranous glomerulonephritis, Nephrotic syndrome morphologically consists of an immune complex glomerulonephritis
, with granular deposits along the glomerular basement membrane and in the mesangium.17,18
The induction of immune dysregulation by HIV may result in hypergammaglobulinemia, suggesting an abnormal polyclonal B-cell activation and immune complex glomerulonephritis
in these patients.