Three different forms of renal irAE have been described so far: acute interstitial nephritis, minimal change disease, and
immune complex glomerulonephritis [4-7].
Levamisole/cocaine induced systemic vasculitis and
immune complex glomerulonephritis. Case Rep Nephrol 2015; 2015:372413, doi: 10.1155/2015/372413.
Kidney biopsy did not demonstrate evidence of a proliferative glomerulonephritis, viral immune defects in glomerular cells, or an
immune complex glomerulonephritis with IgG, IgA, C3 or CMV antigens within glomeruli.
The adverse effects include proteinuria, glomerulitis with haematuria, Membranous glomerulonephritis, Nephrotic syndrome morphologically consists of an
immune complex glomerulonephritis, with granular deposits along the glomerular basement membrane and in the mesangium.17,18
The induction of immune dysregulation by HIV may result in hypergammaglobulinemia, suggesting an abnormal polyclonal B-cell activation and
immune complex glomerulonephritis in these patients.