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References in periodicals archive ?
Spontaneous and miniature inhibitory GABAergic currents (spontaneous inhibitory postsynaptic currents [sIPSCs] and miniature inhibitory postsynaptic currents [mIPSCs]) and their kinetic characters were measured.
Neuronal GABA receptor A (GABA[sub]A) receptors are pentameric chloride ion channels, with synaptic a[sz]a and extrasynaptic a[sz]a isoforms mediating phasic and tonic inhibitions, respectively, whose different subunits arrangement determines individual functions.[sup][12] Phasic inhibition is further subdivided into fast GABA[sub]A (GABA[sub]A, fast) and slow GABA[sub]A(GABA[sub]A, slow) inhibitory postsynaptic currents (IPSCs).
Offline analysis of miniature inhibitory postsynaptic currents (mIPSCs) kinetic parameters was performed using Mini-Analysis 6.0 (Synaptosoft Inc., Decatur, GA, USA).
Neonatal propofol exposure but not etomidate increases the frequency of miniature inhibitory postsynaptic currents but not amplitude in p80–90 rats
Bumetanide blocks the frequency increase and kinetic alteration of miniature inhibitory postsynaptic currents induced by neonatal propofol exposure
Etomidate mediates inhibitory postsynaptic currents through a postsynaptic pathway
Kaba, "Oxytocin depresses spontaneous y-aminobutyric acid-ergic inhibitory postsynaptic currents in cultured mitral cells of the rat olfactory bulb by a presynaptic mechanism," Neuroscience Letters, vol.
In spinal cord slices, TNF[alpha] not only enhances sEPSCs but also suppresses the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) [63].
Nevertheless, functional roles of glycine receptors are largely unknown because glycine is unlikely to be released from presynaptic nerve terminals, and there is no direct evidence for glycinergic inhibitory postsynaptic currents in these brain structures (but see also [6]).
It should be noted that, however, postsynaptic Glycine receptors are unlikely to contribute to the regulation of neuronal excitability, as inhibitory postsynaptic currents are absolutely mediated by [GABA.sub.A] receptors rather than strychnine-sensitive glycine receptors [45].