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References in periodicals archive ?
In the AOP-Wiki database, a MIE involving the peroxisome proliferator-activated receptor gamma (PPAR[gamma]), "PPAR[gamma], activation" (ID 1028 in the AOP-Wiki database) was identified as being connected to other AOP terms such as "increase adipogenesis" and "obesity." Indeed, PPAR[gamma] activation is a known initiating event for increased adipogenesis (Lefterova et al.
Thus, the story reveals a fundamental circularity: its initiating event is unreal and the narrative finishes where it starts.
Guidelines for Initiating Events and Independent Protection Layers in Layer of Protection Analysis
The most important initiating event in access failure is fluid dynamic stress, especially regions of low shear stress and turbulence (Roy-Chaudhury, 2003).
A significant delay in the assessment and response process can be disastrous if the initiating event is of the type that can quickly progress to a dangerous outcome.
Galaris, "Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells," FEBS Journal, vol.
The relationship between psoas abscess and joint infection is understood, but it is difficult to ascertain which is the initiating event. Reports of psoas abscess associated with prosthetic hip infections has only rarely been reported in the literature, but a study concluded that 12% of patients with hip prostheses infections were complicated by psoas abscess formation (5).
"In this work, we show that one of the early changes in Alzheimer's neurons thought to be an initiating event in the course of the disease turns out not to be that significant," Goldstein said, adding that they discovered a different early event plays a bigger role.
The next step was to select the igniter (initiating event).
Study leader Professor Judith Varner, from the University of California at San Diego (UCSD), US, said: "We've found a single convergent point - the PI-3 kinase gamma enzyme - that, when blocked, appears to result in significant suppression of tumour inflammation and growth regardless of the initiating event."
He structures his presentation in four parts: he (1) introduces his interpretation of the parameters of political theology; (2) offers a historical context for the discipline's intellectual development: (3) describes the historical circumstances of the Shoah as the initiating event of contemporary political theology; and (4) looks at political theology from the standpoint of Scripture and the church.
Bend Deputy Fire Marshal Susie Lovisco told reporters that the "initiating event was related to the testing of a rifle by an employee in the south tunnel." That tunnel is the concrete underground firing range used by the firm for ballistics testing.