(redirected from Initiation Factor 2)
IF2Initiation Factor 2
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References in periodicals archive ?
Hood et al., "Inhibition of eukaryotic initiation factor 2 alpha phosphatase reduces tissue damage and improves learning and memory after experimental traumatic brain injury," Journal of Neurotrauma, vol.
The research centred on eukaryotic initiation factor 2 alpha (eIF2alpha) and two enzymes that modify it with a phosphate group; this type of modification is termed phosphorylation.
Marciniak et al., "Cytoprotection by preemptive conditional phosphorylation of translation initiation factor 2," The EMBO Journal, vol.
Selective stimulation of translation of leaderless mRNA by initiation factor 2: evolutionary implications for translation.
In brief, translation initiation includes (1) binding of the GTP-bound form of eukaryotic initiation factor 2 (eIF2) and initiator methionyl-tRNA (met-tRN[A.sub.i]) complex to the small (40S) ribosomal subunit to form the 43S preinitiation complex (PIC), (2) binding of the 43S PIC to the 7-methylguanosine ([m.sup.7]G) cap of the 5' end of messenger RNA (mRNA), and (3) 43S PIC scanning of the mRNA for an AUG initiation codon [24, 25].