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References in periodicals archive ?
The rats from pregnant mothers that were fed high fat diets had lower levels of insulin receptors, leptin receptors and glucose transporter 1 than did rats that came from mothers fed normal diets.
Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia.
Chiloeches et al., "Role of insulin receptor substrate-4in IGF-I-stimulated HEPG2 proliferation," Journal of Hepatology, vol.
The insulin receptor after being activated by binding with insulin promotes the tyrosine phosphorylation of a number of cellular proteins including the IRS proteins which are major physiological targets of the activated insulin receptor kinase.
In fibroblast [42] and muscle cells [43], it was found that serine phosphorylation of the insulin receptor or insulin receptor substrate- (IRS-) 1 is constitutively increased in PCOS women (see Figure 1, in red), which was associated with a reduction in tyrosine phosphorylation of the insulin receptor and IRS [42] and reduced PI3K activity.
Immunohistochemistry for the Insulin Receptor. Four Epac1 floxed and Epac1 Cdh5 Cre-lox mice were euthanized with carbon dioxide and cervical dislocation.
Severe progressive obstructive cardiomyopathy and renal tubular dysfunction in Donohue syndrome with decreased insulin receptor autophosphorylation due to a novel INSR mutation.
Results: No alteration in the content of insulin receptor substrate 2 in both seropositive patients and control samples were detected.
Identification of a vitamin D response element in the human insulin receptor gene promoter.
We also set out to understand the molecular mechanisms involving the activity of the insulin receptor (IR), the IR substrates 1 and 2 (IRS1/2), the phosphoinositol-3-kinase protein (PI3K), and protein kinase B (Akt/PKB), and the regulation of glucose transporter isoform 4 (GLUT4) in response to acute and chronic resistance exercise.
Editor's Note:"GLUT4 and GSK-3(3 are important components in an insulin-induced signal transduction pathway that plays a key role in glucose metabolism," authors Mei Dou, PhD, and colleagues explain."Increased expression of GLUT4 has been associated with enhanced glucose translocation from the exterior to the interior of cells in insulin-sensitive tissues and repression of GSK-3(3 has been shown to enhance insulin receptor activity.
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