Tiengo et al., "Insulin-mediated glucose disposal
in type I diabetes: evidence for insulin resistance," Journal of Clinical Endocrinology and Metabolism, vol.
In a randomized, double-blind, placebo-controlled trial, insulin-mediated glucose disposal
was measured in 12 obese patients with non-insulin dependent DM (NIDDM) on diet alone before and after four weeks of treatment with either placebo or fluoxetine and it was found that fluoxetine improves insulin-mediated glucose disposal
in obese patients with NIDDM (6).
Impaired insulin-induced erythrocyte magnesium accumulation is correlated to impaired insulin-mediated glucose disposal
in type 2 (Non-insulin-dependent) diabetic patients.
Antidiabetes medications were withheld prior to and during the MMTT to assess the impact of bromocriptine-QR on endogenous insulin-mediated glucose disposal
without interference/confounding of results from a potentially changed exogenous insulin dose requirement during the study period.
Relationship between several surrogate estimates of insulin resistance and quantification of insulin-mediated glucose disposal in 490 healthy, nondiabetic volunteers.
Evaluation of octreotide to assess insulin-mediated glucose disposal by the insulin suppression test.
"Insulin-mediated glucose disposal
varies more than sixfold in apparently healthy individuals.
Relationship between insulin-mediated glucose disposal
and regulation of plasma and adipose tissue lipoprotein lipase.
When obesity is associated with higher amounts of upper body, or central, visceral fat, a 40% decrease occurs in insulin-mediated glucose disposal
(9) making an individual more at risk for developing Type 2 diabetes.
Values for insulin-mediated glucose disposal
vary continuously throughout a population of apparently healthy individuals, with at least a sixfold variation between the most insulin sensitive and most insulin resistant of these individuals.
At the same time, the increased lipid oxidation inhibits insulin-mediated glucose disposal
in both the muscles and the liver. Additionally, preferential shunting of substrate away from muscles to adipose tissue is a factor contributing to a self-perpetuating cycle of obesity in these patients.
Carotid artery wall intima-media thickness is associated with insulin-mediated glucose disposal
in men at high and low coronary risk.