Mac-CM challenge impaired insulin action indicated by 61.95% loss of insulin-mediated glucose uptake
. Pretreatment of adipocytes with CRA (10 [micro]M) improved insulin-mediated glucose uptake
(p < 0.05), whereas this action was blocked by co-treatment with compound C (p < 0.05, Fig.
Skeletal muscle is the major tissue in which a decrease of insulin-mediated glucose uptake
is one of the earliest abnormalities indicating insulin resistance.
During the fasting state in GDM, severe insulin resistance is characterized by an overproduction of glucose by the liver; while in the fed state, severe insulin resistance is characterized by a decrease in insulin-mediated glucose uptake
by the muscle (36).
Systemic infection provokes a stress-induced hypermetabolic response through the activation of the hypothalamic-adrenal axis, which in turn increases hepatic glucose production and inhibits insulin-mediated glucose uptake
into skeletal muscles (13).
The mechanism involved increased insulin-mediated glucose uptake
by muscle in the trained leg, increased muscle content of glucose transporter 4, and enhanced expression of insulin signaling proteins (Diabetes 53:294-305, 2004).
According to a 2003 study, patients with type 2 diabetes who supplement each day with magnesium are able to achieve "improved insulin-mediated glucose uptake
." The authors also said that "the benefits deriving from daily magnesium supplementation are [ ...
Dela, "Strength training increases insulin-mediated glucose uptake
, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes," Diabetes, vol.
CPEC and two triterpenoids restored insulin-mediated glucose uptake
Overexpression of miR-223 decreased GLUT4 protein content and inhibited insulin-mediated glucose uptake
in cultured human adipocytes.
Insulin-mediated glucose uptake
by GLUT4 is the rate-limiting step in carbohydrate metabolism.
Strength training increases insulin-mediated glucose uptake
, GLUT4 content, and insulin signaling in skeletal muscle in patients with Type 2 diabetes.