Chavkin, "Eicosanoids inhibit the G-protein-gated inwardly rectifying potassium channel
(Kir3) at the [Na.sup.+]/PI[P.sub.2] gating site," The Journal of Biological Chemistry, vol.
* Recent discovery of a novel mutation in the KCNJ18 gene, which codes for an inwardly rectifying potassium channel
and is controlled by thyroid hormones, promotes greater influx of potassium into the cells.
[K.sub.ATP] channels are heterooctameric complexes consisting of four pore-forming subunits (inwardly rectifying potassium channel
, subfamily J; Kir6.x) and four regulatory sulfonylurea receptor subunits (ATP-binding cassette protein, subfamily C; SURx) .
[K.sub.ATP] channel present in the pancreatic [beta] cells is an octamer composed of four subunits of sulphonylurea receptor (SUR1) and four subunits of inwardly rectifying potassium channel ([K.sub.IR]6.2) as shown in Fig.
Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol Rev 2005; 57 : 509-26.
PDF neurons, Inwardly rectifying potassium channels, Sleep/wake cycle, Kir channels, PDF-Tri neurons.
A subset of specialized inwardly rectifying potassium channels (Kir) had been identified in the Drosophila genome, which encodes three cDNAs dKirI, dKirII and dKirIII.
In order to see any differences in the projection pattern of PDF-neurons lacking potassium channels IRK1, we specifically knocked down the inwardly rectifying potassium channels on the PDF expressing neurons using the RNA interference system in flies.
Loss of inwardly rectifying potassium channels leads to increased day sleep
This resulted in an overall increase in the sleep of the mutant flies lacking the inwardly rectifying potassium channels (Fig.
Inwardly rectifying potassium channels
: their structure, function, and physiological roles.
However, other results showed an inhibitory effect of halothane on Gi proteins in human myocardium (24) and supportive research further revealed that volatile anaesthetics including halothane, isoflurane and enflurane in clinical concentrations may also inhibit G protein-coupled inwardly rectifying potassium channels