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References in periodicals archive ?
Acetyl-CoA serves as substrate in the MVA pathway to synthesize the critical precursor MVA, which is subsequently converted into dimethylallyl pyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP).
Although they are produced from the condensation of the same precursors in all organisms (isopentenyl pyrophosphate and dimethylallyl diphosphate), the evolutionary origin of their biosynthesis remains controversial.
During the blood stages, parasites lacking an apicoplast can grow in the presence of isopentenyl pyrophosphate, demonstrating that isoprenoids are the only metabolites produced in the apicoplast which are needed outside of the organelle.
(2004), the deficiency of P in the vegetable tissue of a plant may reduce the phosphorylation of mevalonic acid, which means the initial step for the synthesis of isopentenyl pyrophosphate, through the classical route of mevalonate synthesised from acetyl coenzyme A, the main precursor of monoterpenes, such as citral and limonene (Bruneton, 1991; Lange et al., 1998).
The scientists identified isopentenyl pyrophosphate, or IPP, as absolutely essential to the malaria parasite's viability during the stage when it invades blood cells.
An obvious target for genetic engineering is the rubber transferase enzyme, the biological catalyst that polymerizes natural rubber from isopentenyl pyrophosphate (IPP), an allylic pyrophosphate (usually farnesyl pyrophosphate, FPP, in vivo) being required to initiate the reaction.
Using the bacteria's natural supply of isopentenyl pyrophosphate (IPP) as five-carbon building blocks, the scientists inserted bacterial genes encoding enzymes that facilitate the synthesis of phytoene (C40), which is the universal carotenoid precursor.
One natural compound that gamma-delta T cells recognize is isopentenyl pyrophosphate, a small organic molecule with a few phosphate groups attached, the researchers report.
However, these results were acquired using [gamma][delta] T cells stimulated by the isoprenoid metabolite isopentenyl pyrophosphate (IPP) in vitro, and whether [gamma][delta] T cells function like APCs under different disease circumstances, particularly tumors remained largely unknown.
Natural rubber is synthesized in vivo via enzymatic polymerization of isopentenyl pyrophosphate (IPP).
In normal human peripheral blood, [gamma][delta] T cells, 70-90% of which are [V[gamma]9.sup.+][V[delta]2.sup.+] T cells, account for about 1-5% of total T cells, and they can be activated by small nonpeptide phosphoantigens (e.g., isopentenyl pyrophosphate, IPP) in a TCR-dependent and non-MHC-limited manner [2, 3].
In normal human peripheral blood, [gamma][delta] T cells, 70-90% of which are V[gamma]9VS2 T cells, account for about 1-5% of total T cells, activated by small nonpeptide phosphoantigens (e.g., isopentenyl pyrophosphate (IPP)) in a TCR-dependent and MHC-not-limited manner [1].