JAK-STAT

AcronymDefinition
JAK-STATJanus Kinase and Signal Transducer and Activator of Transcription (cytology)
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References in periodicals archive ?
Moreover, LILRB1 and LILRB3 genes induce and regulate the JAK-STAT signaling pathway and upregulate Th1, Th2, and Th17 cytokine genes in the chicken cell line.
To control the Jak-STAT pathway activation, three main negative feedback mechanisms have been proposed.
In contrast to TNF-[alpha] and IL-1[beta], IL-6 through its specific receptor gp80 and the shared gp130 subunit, mainly activates the JAK-STAT transduction pathway.
Decker, "The regulation of inflammation by interferons and their STATs," JAK-STAT, vol.
JAK-Stat activation leads to the increased production of lactate and this in turn drives hair follicle stem cell activation and quicker hair growth.
For instance, Jak-STAT and NF-kappa B signaling pathways are proinflammatory cytokine mediated pathways related to immune-mediated inflammation and following damage of cartilage and bone in RA [18].
IFN-[gamma], a potent activator of cell-mediated immunity, could activate the JAK-STAT signaling pathway through interaction with the cytokine receptor, resulting in the induction of SOCS1 and T-bet [46].
Two of the most important cytokine effector pathways are the JAK-STAT and NF-[kappa]B pathways [6].
Cui et al., "Role of the JAK-STAT pathway in protection of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress in PC12 cells," Apoptosis, vol.
Activation of the JAK-STAT pathway has also been demonstrated to confer cardioprotection in both in vitro and in vivo IR models and be involved in the early-phase and late-phase protection induced by IPC [21-23].
The Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathway is an essential signaling pathway of inflammatory cytokines and is activated in DN [2].
Furthermore, agrimonolide inhibited the activation of JNK and p38 MAPKs and decreased the activation of JAK-STAT and NF-[kappa]B in LPS-stimulated macrophages.