JYG is comprised of 8 Chinese herbs, as shown in Table 1.
Forty-eight mice were divided into the following six groups: the control group, the model group, the Compound Indigo capsule (0.68 g/kg/d) treatment group, and the low (0.9g/kg/d), medium (1.4g/kg/d), and high (1.8 g/kg/d) dose JYG groups.
To observe the anti-inflammation effects of JYG, mice with imiquimod-induced psoriasis were used.
However, in the JYG treated groups, a larger number of particles were arranged in a layer of cells within the tail shallow epidermis, and the formation of granular cell layers in mice tail scales was significantly promoted.
JYG treatment reduced levels of NO and MDA in inflammatory lesions to 1.69 [+ or -] 0.19 and 1.26 [+ or -] 0.14 [micro]mol/L, respectively (P < 0.05); there were no significant differences between the JYG treatment group and the positive drug control group (1.48 [+ or -] 0.43 and 1.42 [+ or -] 0.47 [micro]mol/L, resp.; P > 0.05).
JYG, containing 8 different herbs, is a well-known formula created in the 1950s by Han Xia (a well-known Chinese surgeon).
Our results indicate that JYG inhibited the increase in skin thickness and inflammation in IMQ-treated mouse skin, which is caused by hyperplastic basal suprabasal keratinocyte.
In our study, NO and MDA were elevated in imiquimod-induced inflamed skin, and both JYG and QDG reduced the expression levels.
In summary, we demonstrated that JYG is an effective remedy for treating psoriasis in a mouse model, and these effects were the result of inhibited keratinocyte proliferation and reduced NO and MDA expression.