Potassium channels are principally associated with neuronal processes, and Kv7 (or KCNQ) is one of the voltage-gated potassium channels found in both the central and peripheral nervous system (31).
XE 991, a potent and selective inhibitor of voltage-gated Kv7 (or KCNQ) potassium channels, was used in the present study (38).
Kv7 (KCNQ) channel modulators and neuropathic pain.
KCNQ potassium channels in sensory system and neural circuits.
The anti-hyperalgesic activity of retigabine is mediated by KCNQ potassium channel activation.
Jimenez-Diaz, "Amyloid-[beta] modulates the expression of GirK and KCNQ channel genes in the hippocampus," PLoS One, vol.
Fisahn, "Medial septal dysfunction by A[beta]-induced KCNQ channelblock in glutamatergic neurons," Neurobiology of Aging, vol.
Specific drugs that block or open KCNQ
channels will be used to test whether these channels control the excitability of identified nociceptors, and whether activation of these channels might be an effective therapeutic strategy for reducing SCI-induced chronic pain.
KCNQ subfamily of [K.sub.v] has a subtype namely [K.sub.v]7.1 which underlies cardiac [I.sub.Ks].
Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.
(Nasdaq:ICGN), Research Triangle Park, N.C., has reported that the FDA has lifted the partial clinical hold related to the development of ICA-105665, the company's novel orally available small molecule KCNQ potassium channel agonist, for the treatment of epilepsy.
"This compound is a highly selective agonist of KCNQ channel subtypes, and has demonstrated excellent activity in a broad range of preclinical epilepsy models.