Key event Event description Exposure IE Arsenic exposure Molecular KE7
Decreased histone acetylase or increased histone deacetylase activity KE8 Increased histone methyltransferase or decreased histone demethylase activity KE9 Decreased H3K9ac KE10 Increased H3K4me3 Individual AO3 Psychiatric and neurological disorders Key event Key event relationship Exposure IE Sources of human exposure to inorganic arsenic include drinking water, diet, air, and soils (which can contain naturally occurring arsenic or contamination from anthropogenic sources).
1.e4 e5 2.Nf3 Nc6 3.Bb5 a6 4.Ba4 Nf6 5.O-O Be7 6.Re1 b5 7.Bb3 d6 8.c3 O-O 9.h3 Na5 10.Bc2 c5 11.d4 Qc7 12.Nbd2 cxd4 13.cxd4 Bd7 14.Nf1 Rac8 15.Re2 exd4 16.Nxd4 Nc6 17.Be3 h6 18.Ng3 Nxd4 19.Bxd4 Be6 20.Nf5 Bxf5 21.exf5 Rfd8 22.a4 b4 23.Bd3 a5 24.Ba6 Rb8 25.Rc1 Qd7 26.Bb5 Qb7 27.Bc6 Qc7 28.Qe1 Kf8 29.Rec2 Ng8 30.Be4 Qd7 31.Rc7 Qxa4 32.Ba7 [32.f6 gxf6 (32...Bxf6 33.Rxf7+ Kxf7 34.Bd5+) 33.Bh7 Rd7 34.Qe2 Rxc7 35.Rxc7 Bd8] 32...d5 33.Bxd5 Rxd5 34.Bxb8 Qe8 35.Ba7 Rd7 36.Bb6 Rxc7 37.Rxc7 Nf6 38.Qc1 Bd8 39.Rc8 Bxb6 40.Rxe8+ Kxe8 41.Qc6+ Nd7 42.Qa8+ Ke7
43.Kf1 Nf6 44.Qb7+ Nd7 45.Qd5 Ke8 46.Qe4+ Kf8 47.h4 Nf6 48.Qa8+ Ke7
49.Qb7+ Nd7 50.Qe4+ Kf8 51.h5 Nf6 52.Qa8+ Ke7
53.Qb7+ Nd7 54.Qe4+ Kf8 55.Qd5 Ke7
56.Ke2 Ke8 57.Qe4+ 1-0
2 g3 g5 3 Ke2 a6 4 bxa6 bxa6 5 Kf3 Kf7 6 Kg2 Bxg3 7 fxg3 g4 8 Kf2 h5 9 e4 Ke7
10 Bb2 e5 11 Ke3 Kf7 12 a4 Ke7
13 Kd3 Ke6 14 Bc3 Kd7 15 Kc4 Ke6 16 Kc5 f5 17 Bd2 fxe4 18 Be3 a5 19 Kc6 Kf6 20 Kd6 Kf5 21 Kd5 h4 22 gxh4 g3 23 h5 g2 24 h6 Kf6 25 Kxe4 Kg6 26 Kxe5 1:0.
46...Kf6 47 Qf3+ Rf5 48 Qa8 Qf4+ 49 Kb1 Qd6 50 Qh8+ Ke7
51 Qh4+ Ke8 52 Qh7 Rf7 53 Rg8+
Rxe2 31.Rxe2 Qb6 32.Re8+ Rxe8 33.fxe8Q+ Kxe8 34.Qg8+ Ke7
Nxg6 would have avoided most of the problems which follow for black); 31.Qe6 Nf5; 32.Qd7+ Qe7; 33.Qxe7+ Nxe7; 34.Bf6 Nc8; 35.Bd8 Kg7; 36.Kf3 Kf7; 37.Bxc7 Kf6; 38.Ke4 Ke7
; 39.a3 Kd7; 40.Bb8 Ne7; 41.b4 axb4; 42.axb4 Nf5; 43.Ba7 Kc7; 44.c5 bxc5; 45.bxc5 dxc5; 46.Bxc5 Kd7; 47.Ke5 Nh4; 48.Kf6 Ke8; 49.Be3 (white should be able to achieve a win by either Kg7, trying to pick up black's kingside pawns, or by Ke6, trying to usher home the d pawn); 49 ...
Bxd6 but after 16 Qh7+ Kf8 17 cxd6 exf1=Q+18 Rxf1 cxd6 19 Qh8+ Ke7
20 Re1+ the attack continues.
fxe4 30.Bg4+ Ke7
31.f5 Rg5 32.f6+ Kf7 33.Nf5 Bc6 34.Nd6+ Kg8 35.e6 Kh7 36.Bf5+ Rxf5 37.Rg7# 1-0 Jean-Luc, a very strong player, did not make any big tactical errors but ultimately lost through not understanding the nuances of the pawn structure which allowed White to grasp the initiative and build a winning position..
12 Qxd5+ Ke7
13 Bg5 1-0 The next game was won by one of our most brilliant players from the 1950 British Championship at Buxton.
Qh6 after 15..Qg6!; 16 Be7 Bc4; 17Qc4 Ke7
; 18 Qb4+ Ke8 the game is level 16.Bb5+ c6 this weakening of d6 is practically decisive already; 17.Nd6+ Kf8; 18.Bc4 Qf6; 19.Ne4 Bxc4; 20.Qxc4 Qh4; 21.Rd7 Re8; 22.g3 Qg4; 23.Qd3 even better would be 23 Rb7 Qe6; 24Qxe6 fxe6 25 Nd6+ winning; 23...Qe6; 24.Nc5 Bxc5; 25.Bxc5 g5; 26.Rd1 after 26 f3 Kg7; 27 Re5 Qe5; 28 Bd4 wins easily; 26...Kg7 0-1.
The critical line is 15...Bxd6 16.Qh7+ Kf8 17.cxd6 exf1Q+ 18.Rxf1 cxd6 19.Qh8+ Ke7
2O.Re1+ Ne5 21.Qxg7
Nf5 14 dxc5 15 Qg5Nxe5 16 Qxd8+ Kxd8 17 cxb6 axb6 18 Rb1 Ra6 19 Ke2 Ke7
20 g3 Rc8I felt quite pleased with my position, the Ns combining so well in the endgame.