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KLF5Kruppel Like Factor 5
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References in periodicals archive ?
(2012) CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5. Proc.
Pol et al., "Cardiac myocyte KLF5 regulates Ppara expression and cardiac function," Circulation Research, vol.
Both KLF5 and SP1 bind to similar elements within GC-rich promoter sequences of target genes.
In contrast, allelic imbalance in 13q14 harboring tumor suppressors RB1, DBM, FAM10A4, and FOXO1A and 13q21 containing putative tumor suppressors EDNRB and KLF5 was found to be higher in the Japanese population compared to a German cohort [3].
Studies in our laboratory have demonstrated that Klf4 and Klf5 are both required for conjunctival goblet cell development (Figure 3) [54, 65].
0.005, 0.05, Cell cycle c-Jun, 2004 0.25 *, 0.5 *, 1 KLF5 expression *, 5 *, 15 *, 25 * Salazard et al.
Liu, Tala et al., "Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation," Cell Discovery, vol.
Lappas, "KLF5 regulates infection- and inflammation-induced pro-labour mediators in human myometrium," Reproduction, vol.
(98) Mechanistically, CagA-mediated deregulation of Wnt signaling in gastric epithelial cells induces ectopic expression of the Caudal-related homeobox transcription factor Cdx1, which in turn trans-activates reprogramming factors such as Sal-like protein 4 (SALL4) and Kruppel-like factor 5 (KLF5) to confer a stem-cell property in gastric epithelial cells.
NHBE cell lysates were analyzed for Kruppel-like factors 4 and 5 (KLF4 and KLF5) and phospho-KLF4 and phosphor-KLF5 by Western blot.
Taken together, our study on C2C12 cells and/or MC3T3-E1 cells treated with knockout of KLF15 gene or overexpression of KLF5 further confirmed that tanshinol may protect against GC-elicited repression of osteogenesis involved in KLF15 pathway.
Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5. Mol Endocrinol 2010;24:1978-87.