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Ganem, "Effects of NF[kappa]B activation on KSHV latency and lytic reactivation are complex and context-dependent," Virology, vol.
KSHV BCL-2 was shown to block Beclin 1-dependent autophagy in both yeast and mammalian cells .
Sherman et al., "Evidence against KSHV infection in the pathogenesis of multiple myeloma," Virus Research, vol.
Tolllike receptor signaling controls reactivation of KSHV from latency.
They found latent nuclear antigen 1 (LANA-1) of KSHV in 16 cases (62%) when they used immunohistochemistry (Am.
The virus in the new study is Kaposi's sarcoma-associated herpesvirus (KSHV), which causes skin and lymph cancers.
(3,5,6,9) In the presence of HIV, KS is associated with human herpesvirus 8 (HHV-8, also referred to KSHV for KS-associated herpesvirus).
HAART has no direct effect 'against the Kaposi's sarcoma herpes virus (KSHV); it works indirectly by reconstituting the immune system.
The journal Nature reports that the hunting and consumption of bush meat could expose human populations to deadly new viruses such as KSHV, "a herpes virus associated with Kaposi's sarcoma, a form of skin cancer often suffered by people with AIDS."
Eight different herpesviruses that infect humans have been identified to date--herpes simplex viruses 1 and 2 (HSV1 and HSV2), (1) varicella zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpes-viruses 6 and 7 (HHV6 and HHV7), and Kaposi sarcoma-associated herpesvirus (KSHV)--also known as human herpesviruses 1-8 (HHV1-8), respectively.
"Mast cell activation and KSHV infection in Kaposi Sarcoma", Clin Cancer Res., Oct 15, 2018
Kaposi sarcoma associated herpesvirus pathogenesis (KSHV)--an update.
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