Start with the direct route from KSAF to KTBR. It's about 1225 NM.
You now have two legs: KSAF to KFSM, and then KFSM to KTBR. Let's plan the first leg.
Scanning ahead on the direct route from KFSM to KTBR, you note the Columbus MO As just south of Memphis.
To avoid that, you add the Dublin VOR (DBN) just 56 miles from KTBR. Then, between DBN back to UYSEF, you look for fixes to add.