This study contrasts ones showing a decrease in lipid peroxidation and further suggests FvA as a causative factor in Kashin-Beck disease. An underlying factor for elevated oxidative stress is that FvA can increase cellular respiration rates at extended exposure in rat mitochondria, which may lead to the production of more oxygen radicals .
Wang et al., "The role of humic substances in drinking water in Kashin-Beck disease in China," Environmental Health Perspectives, vol.
Association Study of Polymorphisms in SelenoproteinGenes and Kashin-Beck Disease
and Serum Selenium/Iodine Concentration in a Tibetan Population.
In addition T-2 toxin is famous for its possible role though not yet verified in the induction of the endemic Kashin-Beck disease
. In 2001 the European Food Science Committee determined the maximal capacity for short- term T-2/HT-2 co-intake to be 0.06A-10-3 mg/kg/day .
(KBD) was first reported as an endemic degenerative osteoarthritis in 1919 , and this condition affects more than one million individuals  in a limited endemic area in China, Central China, from Southeastern Siberia to North China, and North Korea .
(2) Institute for Kashin-Beck Disease
Control, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, 157 Bao Jian Road, Harbin 150081, China
The first student to study for a joint Swansea/Grenoble PhD is being recruited and will research Kashin-Beck disease
, a condition which stunts the growth and destroys the joints of children and young adults.
For example, elevated concentrations of chromium has been found in the hair of people suffering from diabetes mellitus while Kashin-Beck disease
has been attributed to a selenium deficiency.
, which causes restriction of movement and joint deformity, is endemic to Tibet and associated with low socioeconomic status, poor diet, and iodine deficiency (Suetens et al 2001, Yang et al 2002).
In those regions, people frequently develop Kashin-Beck disease
, which causes joint problems relatively early in life.
In this region two endemic diseases, Keshan disease (juvenile cardiomyopathy) and Kashin-Beck disease
(osteoarthropathy), have been reported.
Chinese scientists have also described another disease that they attribute to selenium deficiency - Kashin-Beck disease
, a form of osteoarthritis occurring during preadolescence and adolescence.