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References in periodicals archive ?
The cohorts are expected to enroll MET-therapy naive and pretreated non-small cell lung cancer patients with exon 14 skipping mutations; patients with MET-amplified non-small cell lung, hepatocellular, gastric or gastroesophageal cancer and patients with other solid tumors harboring MET kinase domain mutations or fusions.
This PCR-based, in vitro diagnostic test detects internal tandem duplication mutations and tyrosine kinase domain mutations D835 and I836 in the FLT3 gene in genomic DNA extracted from mononuclear cells obtained from peripheral blood or bone marrow aspirates of patients diagnosed with AML.
Mutations in the serine/threonine kinase domain have been found in a number of Parkinson's patients where PINK1 fails to protect against stress-induced mitochondrial dysfunction.
JH 1 domain has tyrosine kinase activity so it is called as kinase domain. JH 2 domain has a considerable structural similarity with JH 1, but it does not have enzymatic activity.
Ser/Thr Kinase and protein kinase domain with Ser/Thr activity were vastly found in qBFR4.
The company's XOSPATA has demonstrated inhibitory activity against two different mutations, FLT3 internal tandem duplication (ITD) and FLT3 tyrosine kinase domain (TKD).
Various mutations in ABL1 kinase domain like T315I and others are implicated in resistance to TKI therapy and thereby poor response to treatment17.
The kinase domain of a CDPK becomes active via interaction with its typically C-Terminally located calcium binding domain.
In another 5% of the cases, Exons 13 and 17, encoding the kinase domain of the protein are mutated.
EGFR gene is formed from 28 exons; the tyrosine kinase domain is encoded by exons 18-21.