L-NA

AcronymDefinition
L-NAN Omega-Nitro-L-Arginine
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The C57BL/6J mice were divided into three groups: L-NA group, LPS group, and normal saline (NS) group.
Rapamycin could reduce 24-h urinary protein levels in the PI and EP subgroups of L-NA and LPS, but had no effect on the MAP of L-NA and LPS preeclampsia-like mouse models [Figure 1].{Figure 1}
In the PI and EP subgroups of the L-NA group, hepatocyte ballooning degeneration and loose tissue structure could be observed.
L-NA, indomethacin, ACh, PE, sodium nitroprusside, levcromakalim were obtained from Sigma-Aldrich.
It was also blunted by L-NA (an NO synthase inhibitor) and indomethacin demonstrating the involvement of uncoupled eNOS and cyclooxy-genases (Fig.
Inhibitors of NO synthesis MK-801, AP5 Gold fish Learning of avoidance task MK-801 Mice Learning of avoidance task L-NAME Rats Learning and memory of maze performance Rabbit Eye-blink conditioning Chicks Learning of avoidance task Rats Learning and memory of avoidance task Rats Learning of avoidance task Octopus vulgaris Learning of avoidance task Aplysia Learning of avoidance task Honey bee Learning of olfactory discrimination L-NA Rats Learning and memory of avoidance task Rats Learning and memory of maze performance Rats Learning and memory of maze performance L-NMMA Rats Memory of avoidance task 7-NI Rats Learning and memory of avoidance task Rats Learning and memory of maze performance Chicks Learning of avoidance task 4.
The effect of ergosterol peroxide (13) against NO release was higher than that of CAPE, an NF-kB inhibitor ([IC.sub.50] = 5.6 [micro]M), indomethacin, a non-steroidal anti-inflammatory drug (NSAID, [IC.sub.50] = 25 [micro]M) and L-NA, a NO synthase inhibitor ([IC.sub.50 = 61.8 [micro]M).
The activity of 7 was much higher than that of positive controls, indomethacin (non-steroidal anti-inflammatory drug, NSAID, [IC.sub.50] = 25.0 [micro]M), caffeic acid phenethylester ([IC.sub.50] = 5.6 [micro]M) and L-nitroarginine (L-NA, [IC.sub.50] = 61.8 [micro]M) (Table 1 and Fig.
Compounds [IC.sub.50], ([micro]M) Deguelin (1) 0.008 [alpha]-Toxicarol (2) 0.013 Tephrosin (3) 0.057 6a, 12a-Dehydro-[alpha]-toxicarol (4) 3.235 6a, 12a-Dehydrodeguelin (5) 1.101 Rotenone (6) 0.041 l2a-Hydroxyrotenone (7) 0.002 6a, 12a-Dehydrorotenone (8) 0.233 12a-Hydroxyelliptone (9) 0.010 Indomethacin 25.0 Caffeic acid phenethylester (CAPE) 5.6 L-Nitroarginine (L-NA) 61.8 [FIGURE 2 OMITTED]
L-NA and caffeic acid phenethylester (CAPE) were used as positive controls.
These three compounds also exhibited higher activity than that of indomethacin ([IC.sub.50] = 25.0 [micro]M), a clinically used non-steroidal anti-inflammatory drug (NSAID) and higher than l-NA (NOS inhibitor, [IC.sub.50] = 61.8 [micro]M).