This review is about escapin, an L-amino acid oxidase in the ink of a gastropod mollusc, the sea hare Aplysia californica.
L-amino acid oxidase activity of an antineoplastic factor of a marine mollusc and its relationship to cytotoxicity.
Characterization of L-amino acid oxidase and antimicrobial activity of aplysianin A.
A spectrophotometric microplate assay for L-amino acid oxidase
L-amino acid oxidase (LAAO; EC 220.127.116.11) is usually dimeric flavoprotein containing a noncovalently bound FAD molecule as cofactor for each subunit.
Yoshioka et al., "Inhibition of human platelet aggregation by L-amino acid oxidase purified from Naja naja kaouthia venom," Toxicon, vol.
Escapin is an L-amino acid oxidase that oxidizes its substrates, L-lysine and L-arginine in opaline, when ink and opaline are secreted simultaneously, and produces a complex set of compounds that are mild deterrents against Panulirus interruptus and Callinectes sapidus (Yang et al., 2005; Johnson et al., 2006; Kamio et al., 2007, 2009; Aggio and Derby, 2008) (Fig.
an L-amino acid oxidase in the ink of the sea hare Aplysia californica.
An example is the products of the oxidation of L-lysine (present in high doses in opaline) by escapin (an L-amino acid oxidase that is present only in ink), which are produced only when ink and opaline are co-secreted and mixed in the mantle cavity just prior to release (Kicklighter et al., 2005; Johnson et al., 2006; Kamio et al., 2007).
L-Amino acid oxidase activity of an antineoplastic factor of a marine mollusk and its relationship to cytotoxicity.
Snake venom protein (such as phospholipase A2 metalloproteinases serinoproteases L-amino acid oxidases
lectin and other) and peptides (brady kinin potentiators analgesic peptides and other) have found practical application as pharmaceutical agents with significant therapeutic values.
L-amino acid oxidases
(LAOX) catalyse the stereospecific oxidative deamination of amino acid substrates to the corresponding a-keto acids along with the production of ammonia and hydrogen peroxide via an imino acid intermediate .