is an independent predictor of poor survival in endometrial cancer--An analysis of The Cancer Genome Atlas (TCGA)," Gynecologic Oncology, vol.
plays a key role in the development of the nervous system, regulation of intercellular interactions, migration of nerve cells, growth of neurites on Schwann cells, myelination of nerve fibers, and so on [141-143].
Following DNA isolation from peripheral blood, molecular analysis of L1CAM
gene (NM_000425) was performed using a targeted next generation sequencing panel (the TruSight Inherited Disease[R] panel).
migration ADAM9 E-cadherin Invasion, metastasis [alpha]3, [beta].sub.1], Cell-cell interaction and [alpha]5, [beta].sub.1], ECM degrading capacity, [alpha]6, [beta].sub.1] invasion , MMP upregulation [alpha]6, [beta].sub.1] Inhibition of migration and invasion [alpha]6, [beta].sub.4], Liver metastasis [alpha]2, [beta].sub.1], [alpha]v, [beta].sub.1] ADAM10 CD44 Cell-contact inhibition, metastasis CXCL16, [alpha]v, Migration, metastasis, [beta].sub.3] attraction of cancer cells E-cadherin, cadherin- Cell-cell contact, catenin-interaction invasion, migration L1CAM
Migration N-cadherin, cytoskeletal Migration rearrangement, RAGE Notchl Migration and invasion PI3K/AKT activation Invasion [alpha]5[beta]1 Inhibition metastasis [alpha]v[beta]6, MMP Migration and invasion regulation ADAM12 ?
The neural adhesion molecule L1CAM
confers chemoresistance in human glioblastomas.
Spectrum and detection rate of L1CAM
mutations in isolated and familial cases with clinically suspected L1-disease.
Weidle, "Identification of L1CAM
, Jagged2 and Neuromedin U as ovarian cancer-associated antigens," Oncology Reports, vol.
Warren, Hewitt, and Thomas describe how intrauterine alcohol exposure interferes with the function of L1CAM
, the L1 cell-adhesion molecule.
Like other adhesion molecules, the L1 cell adhesion molecule (L1CAM
) helps cells bind with each other or with other large molecules outside the cell, thereby guiding the growth of cells and ensuring the formation of functional tissues.
However, research conducted by Yamasaki et al in 1997 suggested a link to the L1 protein cell adhesion molecule (L1CAM
) in patients with ACC.
The L1Cell Adhesion Molecule (L1CAM
) gene codes for a glycoprotein with six immunoglobulin (lg)-like domains and five fibronectin-like domains in the extracellular portion (Kohl et al., 1992).
The results confirm the multiple publications demonstrating the role of L1CAM
in the progression of cancer and highlight the potential of L1CAM
targeting therapies as new treatment for several cancer types expressing L1CAM
, added Dr Schmidt.