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James Russell, professor emeritus, Department of Surgery, Metabolic and Cardiovascular Diseases Laboratory at the Alberta Institute for Human Nutrition, University of Alberta, Canada and his colleagues conducted one of the preclinical studies, titled "Metabolic Effects of a Novel Silicate Inositol Complex of the Nitric Oxide Precursor Arginine in the Obese Insulin-resistant JCR: LA-cp Rat." Their research concluded that the arginine silicate inositol complex is absorbed efficiently, raising plasma arginine levels, and is more biologically effective than arginine hydrochloride.