A report in the Centers for Disease Prevention and Control's (CDC) May 26 Morbidity and Mortality Weekly (MMWR) Dispatch noted "acute LCMV
infection in an organ donor is thought to be a rare event.
During summer 2012, state and local agencies and the Centers for Disease Control and Prevention (CDC; Atlanta, GA, USA) investigated an outbreak of LCMV
in the United States.
testing of other rodents at the pet store identified three other LCMV
-infected rodents (two hamsters and a guinea pig).
is a rodent-borne arenavirus endemic in house mouse (Mus musculus) populations worldwide (3-5).
infection was defined as a diagnosis of meningitis, choriomeningitis, encephalitis, or meningoencephalitis not explained by another etiologic agent.
To determine the source of LCMV
infection, investigations were conducted at the hospitals involved in organ recovery and transplantation and at the coordinating organ procurement organization.
Reverse transcription PCR (RT-PCR) and sequencing indicated LCMV
Historically, in Spain, LCMV
was detected in 1 person with encephalitis (5) and 4 persons with meningitis (6).
Early data suggested [less than or equal to] 8% of central nervous system manifestations of viral etiology were caused by LCMV
Five South American members of the Tacaribe serocomplex, LCMV
, and Lassa virus are etiologic agents of severe febrile illnesses in humans (10,11).
is rarely reported to public health departments or in the literature.
is primarily maintained in the common house mouse (Mus musculus andM.