The immunophenotypic profiles of SCLC and LCNEC are highly similar.
Immunohistochemistry of Neuroendocrine Tumors of the Lung Immunostain TC AC LCNEC SCLC AE1/AE3 (a) POS POS POS POS CAM5.
In particular, NOTCH genes family alterations represent one of the most relevant differences in NSCLC-like LCNEC
from classic lung adenocarcinoma and are of particular interest because they give a strong evidence for their crucial role of Notch receptors in neuroendocrine fate specifications in normal and tumor development [55, 57].
This article represents the first review in the English literature that has compiled data about patients' demographics, presenting symptoms and treatment exclusively on LCNEC
CgA was selected in this study as a NE marker for supporting the diagnosis of PNECs, especially the SCLC & LCNEC
, and also to sobserve its association with HDC immunostaining.
8-11) Herein, we evaluate the specificity and sensitivity of mASH1 in various normal and neoplastic tissues, with emphasis on non-neuroendocrine carcinoma/neuroendocrine tumor cancers and demonstrate the specificity of mASH1 in SCLC, and LCNEC versus nonneuroendocrine NSCLC, including adenocarcinoma, squamous cell, classic large cell, and carcinoids (neuroendocrine tumors).
9% (1 of 111) of squamous cell carcinomas, and 0% (0 of 30) of large cell carcinomas, and LCNEC stained 66.
Recent studies have shown that there are more similarities than differences between SCLC and LCNEC.
Classification of thymic NETs is similar to that of pulmonary NETs, including TC, AC, LCNEC, and small cell carcinoma.
For the 35 LCNEC
tissues (women, 1 [3%]; men, 34 [97%]), the mean (SD) age at presentation was 64 (9) years.
The prognosis associated with LCNEC
is less well defined.
11) The role of paxillin in LCNEC
and carcinoid has not been well studied.