References in periodicals archive ?
Menin interacted with MLL as an adaptor protein to link it to LEDGF, a protein that is required for MLL to regulate transcription and that, more importantly, played a role in MLL-dependent leukemic transformation [10].
Cleary, "Menin critically links MLL proteins with LEDGF on cancer-associated target genes," Cancer Cell, vol.
Casiano, "Autoimmunity to the nuclear autoantigen DFS70 (LEDGF): what exactly are the autoantibodies trying to tell us?" Arthritis & Rheumatism, vol.
LEDGF contains a putatively chromatin-binding N-terminal fragment, as well as an Integrase Binding Domain (IBD) that is mapped to the C-terminal end (residues 347-429) [40,68].
The function of LEDGF for IN has been corroborated by analysis of integration sites in human cells depleted for LEDGF/p75 and in embryonic fibroblasts derived from LEDGF/p75 KO mice, both demonstrating a role for LEDGF/p75 during target site selection [44,65,70].
LEDGF appears to be important during embryonic development, since the majority of homozygous LEDGF KO mice die perinatally and survivors display a range of abnormal phenotypes, compatible with defects in homeodomain proteins [84].
LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes.
Abbreviations ANA: Antinuclear antibody DFS: Dense fine speckled CIA: Chemiluminescent immunoassay IBD: Inflammatory bowel disease IIF: Indirect immunofluorescence LEDGF: Lens derived epithelium growth factor HI: Healthy individuals LR: Likelihood ratio RA: Rheumatoid arthritis SARD: Systemic autoimmune rheumatic diseases SSc: Systemic sclerosis SLE: Systemic lupus erythematosus SLEDAI: SLE disease activity index SSc: Systemic sclerosis.
Chylack Jr., "Review: age-related cataract: immunity and lens epithelium-derived growth factor (LEDGF)," Journal of Ocular Pharmacology and 'ttierapeutics, vol.
Shinohara et al., "Humoral immune response directed against LEDGF in patients with VKH," Immunology Letters, vol.