LEF1

AcronymDefinition
LEF1Lymphoid Enhancer-Binding Factor 1
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References in periodicals archive ?
Indeed, within the top 20 Wnt3a upregulated genes we observed 6 transcription factors: Lef1, Ahr, Gata2, Id2, Msx2, and Sp5, that are target genes or functional partners with components of the signaling cascade and that play a role in synaptic development.
In this study, we also predicted potential TFs of DEGs, such as LEF1, NFAT, and SP1.
Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland.
Shen et al., "Dysregulation of TNF[alpha]-induced necroptotic signaling in chronic lymphocytic leukemia: suppression of CYLD gene by LEF1," Leukemia, vol.
The expression of LEF1 protein was not significantly affected in cells exposed to the patients sera, whereas LEF1-[DELTA]N was strongly inhibited in cells exposed to all obese groups (Figures 3(a) and 3(b)).
Interestingly, a group of 30 DEGs are found connected functionally, including LEF1, KLRC3, PCNA, IFNAR1, IL7R, CCL5, CXCR3, CAV1, and TLR7 (Figure 4).
SVMicrO-based Expression Gene prediction correlation Final symbol score Score P value Score P value FOXP1 1.066 0.0043 0.508 0.016 1212 VEZF1 0.942 0.0060 0.4868 0.020 1179 NOVA1 0.896 0.0067 0.479 0.023 1160 CPEB3 0.858 0.0074 0.484 0.022 1149 MAP2K4 0.919 0.0064 0.322 0.097 1139 FAM120A 0.885 0.0069 0.341 0.082 1130 PCDHA3 0.983 0.0054 0.170 0.215 1125 SIRT1 0.927 0.0062 0.230 0.162 1117 PCDHA5 0.983 0.0054 0.148 0.233 1113 PTEN 0.898 0.0067 0.221 0.168 1104 PCDHA1 0.983 0.0054 0.140 0.239 1103 NBEA 0.752 0.0098 0.491 0.020 1102 ZFHX4 0.970 0.0056 0.154 0.229 1097 GLCE 0.798 0.0087 0.3231 0.096 1096 MAGI2 0.777 0.0092 0.321 0.097 1086 SATB2 0.801 0.0086 0.243 0.151 1078 LEF1 0.753 0.0098 0.291 0.112 1065 ATPBD4 0.819 0.0082 0.170 0.215 1060
In contrast, genes involved in stem cell maintenance, such as cell adhesion molecules, WNT, and Notch-signaling pathway components, CDH1, SERPINF1, LEF1, FRZB1, KRT19, SOD2, and EGR1, were overexpressed in the limbal crypt [44].
The Lymphoid enhancer-binding factor 1 (LEF1) is a nuclear transducer that indicates a link between Wnt signaling and PCa, as Wnt1 leads to activation of LEF1 and it increases AR transcription [46].
Fgf4 is activated by LEF1 from the Wnt pathway, is expressed only in the knot, and is responsible for enamel epithelium and dental papilla proliferation [Miletich and Sharpe, 2003; Zhang et al., 2005].