LETMLongitudinal Extensive Transverse Myelitis (spinal cord lesion)
LETMLiving Eternally Today Ministries
LETMLake Evaporation and Thermodynamics Model
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References in periodicals archive ?
Neuromyelitis optica is considered a more aggressive inflammatory disease than MS and is typically characterized by an LETM i.e., a myelitis that extends over the distance of three vertebral bodies along with severe (and not uncommonly) bilatera optic neuritis (4).
CSF tests revealed slight increases in nuclear cell count and total protein level in 2 LETM patients.
In NMO and LETM patients, the maculate enhancement lesions mainly located in the central of cervical and thoracic spinal cord [Figure 3].
In the case of our patient, she mostly had a neurological involvement as later confirmed by pathology (lupus cerebritis) and imaging (LETM).
Most sources describe LETM as a rare and serious inflammatory process that expands over more than three vertebrae, (5-10) though some have described it as more than four.
Spinal cord MRI demonstrated LETM in seven NMO patients with detectable IFN-[alpha] (five being anti-AQP4 seropositive).
One patient had detectable IFN-[beta] as well as IFN-[alpha] and had acute relapse with LETM. No SLE patients had measurable serum IFN-[beta].
In section 1.3, the appropriateness of the model is checked with the help of Log-Linear Transformation Model (LLTM) and Log-Exponential Transformation Model (LETM).
In this section we will test the appropriateness of the reverse and direct methods by using Log-Linear Transformation Model (LLTM) and Log-ExponentialTransformation Model (LETM).
Initially, NMO-IgG was detected in 11/29 patients presenting with LETM, (3) and 6/9 of these patients were found to relapse within 2 years, whereas none of the 14 NMO-IgG negative LETM patients relapsed within 4 years of follow-up.
In a review of literature by Jarius and Wildemann, the frequency of anti-AQP4 antibody in patients with longitudinally extensive transverse myelitis (LETM) ranged between 0% and 100% with a median of 53.3% [18].