LIBCSPLong Island Breast Cancer Study Project (Connecticut and New York study; National Cancer Institute)
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Women with BC were enrolled into the LIBCSP, on average within 3 mo of diagnosis (25th percentile = 1.2 mo, 75th percentile = 4.0 mo).
That MHINCH was undetectable was not surprising given that LIBCSP samples were collected prior to the commercial introduction of DINCH in the United States in 2002 (BASF 2015).
"The LIBCSP studies were able to fairly conclusively rule out several suspected environmental agents."
When those first five studies ended, the LIBCSP did not disappear; it simply entered its next phase of research.
Case-control sample sizes taking into account LIBCSP subject selection procedures, participation rates, and vehicular traffic exposure data availability are presented in the Supplemental Material, Table S1.
The LIBCSP has been enormously productive, continuing even now, with > 100 scientific publications and $21 million in grant funding using LIBCSP resources.
For the LIBCSP, a group of organizations, collectively called the Long Island Breast Cancer Network, met regularly with the primary investigator (PI) of the study, which had some impact on the research (McCormick et al.
Previously published results from the LIBCSP show p53 overexpression in 36% of tumor samples (Rossner et al.
The goal of our present analysis was to investigate whether multiple GST polymorphisms modified the relationship between PAH exposure and breast cancer, using the lymphocyte PAH-DNA adduct biomarker as our primary exposure measure of interest using a large, population-based sample of cases and controls from the LIBCSP. We also evaluated the interaction between GST polymorphisms and smoking status, because smoking behavior was previously identified as the strongest predictor of detectable PAH-DNA adducts (Shantakumar et al.
For this purpose we used samples collected in the LIBCSP from subsets of subjects: a) soil PAHs at residence, b) carpet PAH, and c) PAH-DNA adducts assessed in peripheral blood.
The LIBCSP was the first of the activist-generated studies to become nationally visible.
The results disappointed the activists whose lobbying spawned the LIBCSP. Many believe the studys should have looked at currently used pesticides rather than the long-banned organochlorines.