In humans, LIF is expressed in the endometrial glands during the luteal phase of the menstrual cycle, and LIFR
and GP130 are expressed in endometrial luminal epithelial cells during the cycle and in decidual stroma during early pregnancy [7, 8].
Another study showed that photoreceptor-specific Gp130 knockout mice had accelerated photoreceptor degeneration in an animal model of retinitis pigmentosa. Gp130 activation in the photoreceptors had a general protective role independent of whether stress was caused by light or genetic mutations. Similar findings were reported by other studies showing that the photoreceptors with inherited retinal degeneration died faster in the absence of LIF  or in the presence of a LIFR
antagonist. Joly et al.
The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR
By studying the genetic material of 19 patients who had been diagnosed with either Stuve-Wiedemann syndrome or SJS type II, investigators found that all patients had null mutations in their LIFR
gene at the above-mentioned locus.
This article has given me a renewed focus on where the risks really lie on LIFR
Leukemia inhibitory factor (LIF), a pleiotropic cytokine from interleukin- (IL-) 6 family, regulates various cellular functions via binding to membrane-bound LIF receptor (LIFR
) and gp130 .
Rezaeian et al., "LIFR
is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker," Nature Medicine, vol.
When we took into account the functional grouping as described above, these upregulated genes belonged to chemokines/cytokines and receptors (IL10, IL1b, IL6, and LifR
, Figure 3(d)), neurotrophins and receptors (Bdnf, Gmfb, Hcrtr1, Ucn, and Ngfr, Figure 3(f)), and signaling molecules (c-jun, Figure 3(e)).
Thus, SOCS5 has been shown to negatively regulate EGFR in vitro [119, 121] and more weakly IL-6R, LIFR
, and IL-4R signalling .
We also analyzed 2 of the circulating factors reported as potential target genes and possible candidates for each interaction [leukemia inhibitory factor receptor (LIFR
) and vascular endothelial growth factor A (VEGFA)] in plasma by ELISA (Abcam).
Reporting in Nature Medicine, a research team describes using high-throughput RNA sequencing to identify the leukemia inhibitory factor receptor (LIFR
) as a novel suppressor of breast cancer metastasis, the spread of the disease to other organs.
We'd like to see the actual ceilings and visibilities in this list, however, rather than just an icon for VFR to LIFR
. The icon does show winds and cloud cover.