LMCADLeft Main Coronary Artery Disease
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References in periodicals archive ?
In this cohort, 488 patients (31.6%) were diagnosed with LMCAD, and 1057 patients (68.4%) had MPCAD.
Association between Single Nucleotide Polymorphisms (SNPs) and LMCAD. We successfully genotyped all the three SNPs with genotyping values at least more than 97%.
To further study whether rs5277 affects clinical outcomes in CAD patients, we performed survival analyses in all the CAD patients, LMCAD subgroup, and MPCAD subgroup.
As rs5277 C allele increased the risk of LMCAD, we studied the association of rs5277 and prognosis in LMCAD subgroup and MPCAD subgroup, respectively.
With a moderate size cohort of 1544 CAD patients, we found that COX-2 rs5277 C allele carriage is associated with higher prevalence of LMCAD, and this risk allele also increases long-term risk of adverse events in both CAD and LMCAD patients.
Our findings are supported by previous reports, which demonstrated that LMCAD has a higher heritability and identified several genetic variants associating with increase of LMCAD risk [3-9].
Since atherosclerosis is an inflammatory disease [11], it is reasonable that, in the long-term endurance of left main coronary lesion, COX-2 plays an important role in prognosis among LMCAD patients.
Second, the correlation between COX-2 and LMCAD was based on just three SNPs, which limited the comprehensive view of the genetic variability underlying these phenotypes; further, fine-mapping analyses might give insights into the pathophysiological mechanisms underlying LMCAD.