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It is known that the PDF neuropeptide expressing (LNv) are especially important for morning anticipation and called the morning (M) cells, while dorsal lateral neurons (LNd) and dorsal neuron (DN1) underlie evening anticipation and are called evening (E) cells.
The extent and performance of a lymph node dissection (LND) was physician- and institution-dependent.
Only 11% of patients did not undergo a formal LND. Of the total 1180 patients, 321 (27%) received adjuvant chemotherapy, whereas 859 (73%) did not.
By comparing pN0 patients (having either standard or extended LND) to pNX patients who did not undergo a LND, a significantly improved survival was found in OS, DSS and RFS (log-rank p = 0.0035, 0.0241 and 0.0383, respectively) (Fig.
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