LOCFLast Observation Carried Forward (psychiatric clinical reseach)
LOCFLove of Christ Fellowship
References in periodicals archive ?
For the opioids, 10 of the 11 trials used the ITT analysis six utilized the LOCF approach, but the other trials did not specify any approach.
In Tables 2 to 4, we have applied the repeated significance tests approach to the LOCF imputed response profiles.
LOCF analysis assumes the patient's functional status has not changed.
Both methods have statistical limitations, but LOCF generally is preferred because it accounts for every subject who enrolled in the study.
22(14) LOCF denotes last observation carried forward; CI, confidence interval.
Moreover, we used the LOCF methodology in our analysis to ensure that all enrolled patients were represented in the data at all follow-up time points.
Both PP and LOCF analyses indicated improvements in the 7 dimensions that were interrogated to indicate quality of life.
The analyses were carried out on the basis of "Intention to treat" (ITT) using the LOCF approach and a modified "Per Protocol" (mPP) with any drop-outs being excluded from subsequent analyses.
Because in the Kava group 5 drop-outs occurred whereas in the Opipramol group not one patient withdrew, the main analysis was performed with the ITT population applying the LOCF procedure to ensure a more conservative approach avoiding any bias in favour of Kava.