"A good lod
, Jamie," he commented, "but a stiff one ot carryun' on.
"We were able to demonstrate that Pebble Beach Systems' Orca had the maturity to meet our needs," said Jean-Louis Lods
, Director of Business Development at DMC.
Calculation of Enhancement Factors (EFs) and Limits of Detection (LODs
To avoid confusion the use of the term "analytical sensitivity" is discouraged and it is recommended rather to use limit of the blank (LoB) and limit of detection (LoD
) when discussing the detection capability of a measurement system (6, 7).
Because each laboratory uses a laboratory-developed test to detect MRD by flow cytometry, we expected some heterogeneity in the LODs
of the MRD assays.
A total of two different trajectories were presented for the different LODs
(zones 1 and 6) (Figure 2).
were determined daily: BPS urine (0.01-0.02 ng/mL) and BPS serum (0.002-0.01 ng/mL).
Several studies have shown differences in 99th percentiles among men and women, especially for hs cardiac troponin assays with the ability to measure cardiac troponin concentrations above the limit of detection (LoD
) of the assay in >50% of normal study participants (Table 2).
All urinary metabolite concentrations < LOD
were set to 0.0 except for the analyses of intraclass correlation coefficients (ICCs) or if ln-transformation was used; in these cases, data < LOD
were set to LOD
divided by the square root of 2.
We considered fetal DNA to be present in the maternal plasma or urine if the fetal DNA percentage was above the limit of detection (LOD